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A Cooperative Investigation with the Lehigh University Department of Biology and Barry Bean, M.D.
During the final stages of the normal development of human sperm cells—and during their lifetime after maturing—dynamic changes in the cell surface features take place. Some of these sperm surface structures are particularly important during the events that lead to fertilization. Interactions between sperm cells and the egg cell are highly specific. Features of the initial binding include triggering the opening of a sperm compartment called the acrosome and the recognition and fusion of the sperm and egg plasma membranes. The goal of this investigation is to gain better understanding of sperm structures that function during sperm-egg interactions.
In order to evaluate sperm function in the laboratory, we conduct a series of tests that experimentally "imitate" various processes associated with fertilization. No actual human fertilizations are performed. Once sample evaluation at Lehigh University is completed, samples will be destroyed.
Some people experience a type of infertility associated with the development of an immune reaction against human sperm. This unexpected reaction to sperm cells can occur in either men or women and results in the presence of antibodies that have a specific ability to compromise sperm functions. By identifying the targets of such antibodies on the sperm cell, we hope to learn more about the specific interactions between sperm and egg cells that are essential for fertilization in humans. If such processes can be understood, new approaches to the diagnosis and treatment of certain types of infertility may become realistic. In addition, new approaches for the development of contraceptives may be possible.
Only blood and semen specimens that have already been screened and found to be positive for the presence of antisperm antibodies at the Abington IVF and Genetics, Toll Center for Reproductive Sciences will be used. In addition, specimens may be used in experiments to test their reactivity with natural or artificial antibodies and/or other molecules that have affinity for the sperm cell. The research conducted at Lehigh in conjunction with Drs. Somkuti, Schinfeld and Barmat at the Abington IVF and Genetics, Toll Center for Reproductive Sciences is not identical with clinical laboratory tests that may be ordered during the course of an infertility analysis. The results are not intended to substitute for a clinical analysis. While the results may be available to the donor, Drs. Somkuti, Schinfeld and Barmat; the Toll Center for Reproductive Sciences; Lehigh University; and the Lehigh investigators assume no responsibility for the outcomes, interpretation, or consequences of any research results or research opinions that are developed.
For more information, please call 215-481-4876.
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